Rapid catch-up growth subsequent to undernourishment in utero and metabolic syndrome in later life

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390273
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Embryonic/Neonatal medicine
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: ITOH Hiroaki 浜松医科大学, 医学部附属病院, 教授 (70263085)
• Co-Investigator(Kenkyū-buntansha): SUGIHARA Kazuhiro 浜松医科大学, 医学部, 准教授 (00265878) ; SUZUKI Kazunao 浜松医科大学, 医学部附属病院, 助教 (50456571)
• Co-Investigator(Renkei-kenkyūsha): OGAWA Yoshihiro 東京医科歯科大学, 難治疾患研究所, 教授 (70291424) ; MASUZAKI Hiroaki 京都大学, 医学研究科, 講師 ; TUCHIYA Knji 浜松医科大学, 子どものこころの発達研究センター, 助教 ; MATSUZAKI Hideo 大阪大学, 子どものこころの発達研究センター, 特任准教授 ; UDAGAWA Jun 島根大学, 医学部, 講師
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 妊娠 / 生活習慣病 / 肥満 / 低出生体重 / DOHaD / 慢性炎症 / 脂肪

Outline of Final Research Achievements

Prospective cohort study showed that average energy intake in Japanese pregnant women in Hamamatsu City was slightly less than 1,600 k cal/day, being much lower than the governmental recommendation. Therefore, considerable numbers of fetuses are supposed to be undernourished. By using a mice animal model of undernourishment in utero, we demonstrated the “Catch-Up-Related Adipose Tissue Remodeling Hypothesis ”, that is rapid catch-up growth subsequent to undernourishment in utero may induce chronic inflammation and remodeling in adipose tissue in later life and be causatively associated with the development of metabolic syndrome.

Free Research Field

周産期医学