2014 Fiscal Year Final Research Report
Investigation for pathogenesis of cutaneous severe adverse drug reaction.
| Project/Area Number |
24390275
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
ABE Riichiro 北海道大学, 医学(系)研究科(研究院), 准教授 (60344511)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Yasuyuki 北海道大学, 北海道大学病院, 助教 (80374437)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 薬疹 / アレルギー |
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| Outline of Final Research Achievements |
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening, cutaneous adverse drug reactions that are accompanied by keratinocyte cell death. Dead keratinocytes from SJS/TEN lesions exhibited necrosis, bymorphological criteria. We identified annexin A1 as a key mediator of keratinocyte death via formyl peptide receptor 1 (FPR1). Our results demonstrate that a necroptosis pathway, likely mediated by annexin 1 acting through the FPR1 receptor, contributes to SJS/TEN.
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| Free Research Field |
皮膚科
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