Development of cancer therapy targeting Hedgehog signaling network

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390303
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyushu University
• Principal Investigator: KATANO Mitsuo 九州大学, 医学(系)研究科(研究院), 教授 (10145203)
• Co-Investigator(Kenkyū-buntansha): ONISHI Hideya 九州大学, 大学院医学研究院, 准教授 (30553276) ; NAKANO Kenji 九州大学, 先端融合医療レドックスナビ研究拠点, 教授 (00315061) ; TANAKA Masao 九州大学, 大学院医学研究院, 教授 (30163570) ; ODA Yoshinao 九州大学, 大学院医学研究院, 教授 (70291515) ; NOMURA Masatoshi 九州大学, 大学病院, 講師 (30315080) ; NAKAMURA Katsuya 九州大学, 大学病院, 助教 (60585743)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Hedgehogシグナル / 悪性形質誘導 / Gli1 / ＴｒｋＢ／ＢＤＮＦシグナル / CD24分子 / 低酸素環境 / 増殖能 / 浸潤能

Outline of Final Research Achievements

1)Lung cancer:In Large cell neuroendocrine carcinoma(LCNEC) which is one of neuroendocrine tumors, has high potential of malignancy and there is no standard chemothrapy, TrkB/BDNF signaling is highly activated and can be a therapeutic target. 2)breast cancer:we showed that CD24 molecule regulates Shh that is a ligand of Hh signaling pathway and induces malignant phenotype in breast cancer.3)gallbladder cancer:we confirmed that Hh signaling is activated and it can be a therapeutic target.4)pancreatic cancer:Hh signaling contributes to the reoxygenation-related malignant phenotype induction.5)colon cancer:we revealed that Gli3 pathway can be a new therapeutic target for colon cancer.

Free Research Field

分子生物学