2014 Fiscal Year Final Research Report
macro-cosmos in interaction between cancer and host microenvironments.
| Project/Area Number |
24390315
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Osaka University |
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Principal Investigator |
YAMAMOTO Hirofumi 大阪大学, 医学(系)研究科(研究院), 准教授 (30322184)
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| Co-Investigator(Kenkyū-buntansha) |
MORI Masaki 大阪大学, 大学院医学系研究科, 教授 (70190999)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | hypoxia / microRNA / micrometastasis / C4.4A / invasion / disease recurrence |
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| Outline of Final Research Achievements |
Cancer progression should be understood with respect to cancer features as well as the biological response of the patient’ body. To concur cancers we need to understand tumor behaviors from early cancers to advanced ones. In this project we successfully clarified clinical significance of very early tumor cells, role of a key molecule involved in EMT, role of a hypoxic condition surrounding tumor cells in tumor progression, and we developed a novel nucleic acid medicine against therapy-resistant cancers.
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| Free Research Field |
消化器外科
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