2014 Fiscal Year Final Research Report
Protective effect of ischemic preconditioning for spinal cord ischemia
| Project/Area Number |
24390330
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MIKAMO Akihito 山口大学, 医学(系)研究科(研究院), 准教授 (30372709)
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| Co-Investigator(Kenkyū-buntansha) |
HAMANO Kimikazu 山口大学, 大学院医学系研究科, 教授 (60263787)
LI Tao-sheng 長崎大学, 原爆後障害医療研究所, 教授 (50379997)
KUBO Masayuki 岡山大学, 大学院医歯薬学総合研究科, 助教 (60420519)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 虚血プレコンディショニング |
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| Outline of Final Research Achievements |
A remote IPC (ischemic pre-conditioning) model was carried out in C57BL/6 followed by SCI (spinal cord ischemia). A remote IPC showed protective effect on SCI. Expression levels of DKK1, IL10 and FGF9 RNA in CD34-positive bone marrow cells were 10-times higher compared to CD34-negative bone marrow cells. Our data suggested that ischemic protective factors and anti-inflammatory cytokine secreted by bone marrow stem cells had a functional role in SCI.
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| Free Research Field |
心臓血管外科学
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