Anti-angiogenic therapy for glioma beyond VEGF inhibition based on tumor microenvironment

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390339
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: TAKANO Shingo 筑波大学, 附属病院, 病院講師 (50292553)
• Co-Investigator(Kenkyū-buntansha): KUBOTA YOshinori 慶應義塾大学, 医学部, 教授 (50348687) ; YAMASHITA Toshiharu 筑波大学, 医学医療系, 助教 (50400677) ; EMA Masatsugu 滋賀医科大学, 動物生命科学研究センター, 教授 (60359578)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 神経膠腫 / 血管新生 / 微小環境 / 周皮細胞 / RANTES / VEGF / 神経血管ワイアリング / SDF1

Outline of Final Research Achievements

Crosstalk between tumor cells and cells composed of tumor microenvironment as well as endothelial cells is important for glioma angiogenesis. Glioma angiogenesis evaluated by endothelial cell tube formation induced by glioma conditioned medium. Glioma tube formation was stimulated by tumor stem cell, mesenchymal stem cell and pericyte. The target molecules for stimulation of tube formation were determined RANTES, but not SDF-1. Further studies, such as RANTES targeted animal study and new crosstalk molecule, neurovascular wiring molecule are needed for clinical use of these molecules as antiangiogenic agent.

Free Research Field

脳神経外科