Development of efficient drug and gene delivery system for malignant brain tumors using polymeric nanomicelles.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390340
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: The University of Tokyo
• Principal Investigator: INO Yasushi 東京大学, 医科学研究所, 准教授 (50372371)
• Co-Investigator(Kenkyū-buntansha): KATAOKA Kazunori 東京大学, 大学院工学系研究科, 教授 (00130245)
• Co-Investigator(Renkei-kenkyūsha): NISHIYAMA Nobuhiro 東京工業大学, 資源化学研究所, 教授 (10372385) ; TODO Tomoki 東京大学, 医科学研究所, 教授 (80272566)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 悪性脳腫瘍 / ドラッグ・デリバリー

Outline of Final Research Achievements

We performed a basic research on the method to enhance the efficacy of polymeric nanomicelles as a drug and gene delivery system. The polymeric nanomicelles consist of block polymers which were designed to achieve selective and efficient accumulation to solid tumors including brain tumors. In order to use the polymeric nanomicelles in combination with oncolytic HSV-1 virus therapy, several in vivo mice tumor models were studied, mainly using marker gene expressing HSV-1. When RGD peptide was used as a ligand to αvβ3 and αvβ5 integrins, the functional micelle showed improved accumulation to αvβ3 and αvβ5 integrin expressing tumor tissue and enhanced antitumor effect in vivo

Free Research Field

悪性脳腫瘍学・ウイルス療法・遺伝子治療