2014 Fiscal Year Final Research Report
A role of Lotus, a novel axon growth promoting factor, in post-ischemic neuronal regeneration
| Project/Area Number |
24390346
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KAWAHARA Nobutaka 横浜市立大学, 医学(系)研究科(研究院), 教授 (60214673)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEI Koutarou 横浜市立大学, 医学研究科, 教授 (40202163)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 脳虚血 / 神経再生 / 軸索 / 脳梗塞 / 機能回復 |
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| Outline of Final Research Achievements |
We investigated a role of a novel axon growth promoting factor Louts in neurogenesis and functional recovery after Stroke. Lotus knockout mouse exhibited inhibition of neural progenitor migration in the hippocampus, suggesting a role in neurogenesis. In the stoke model, Lotus transgenic mouse exhibited better recover of motor function compared with wild type, suggesting a new therapeutic regenerative strategy for ischemic stroke.
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| Free Research Field |
脳神経外科学
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