2015 Fiscal Year Final Research Report
Analysis of regulatory mechanisms controlling proliferation and differentiation of chondrocytes
| Project/Area Number |
24390354
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | chondrocyte / Cyp26b1 / iPS cells / collagen / differentiation |
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| Outline of Final Research Achievements |
We analyzed function of Cyp26b1 in chondrocytes by using conditional knockout mice which lack Cyp26b1 in chondrocyte-specific manner. The mice showed abnormal chondrocyte differentiation and cartilage formation, and short limbs. We also created iPS cell model from the disease in which chondrocyte differentiation is abnormal, and analyzed their pathology.
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| Free Research Field |
骨軟骨代謝学
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