2014 Fiscal Year Final Research Report
Study on the usefulness of p2PSA as a predictor of clinical progression in prostate cancer patients undergoing active surveillance
| Project/Area Number |
24390369
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Mikio 香川大学, 医学部附属病院, 准教授 (10243768)
TYOU Ka 香川大学, 医学部, 助教 (30524061)
HIRAMA Hiromi 香川大学, 医学部附属病院, 助教 (50552725)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 低リスク前立腺癌 / PSA監視療法 / p2PSA |
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| Outline of Final Research Achievements |
In the Japanese multicenter study cohort (the 1st cohort of this project), predictive value of serum p2PSA-related indices and other clinicopathological features at the time of starting active surveillance (AS) for the pathological reclassification at 1 year re-biopsy were investigated. By multivariate logistic regression analysis, baseline %p2PSA and ‘Phi (the Prostate Health Index)’ were the only independent predictive factors for pathological upgrade at 1 year after AS commencement.
In the PRIAS-JAPAN study cohort (the 2nd cohort of this project), longitudinally stored frozen sera are under collection from patients who are newly enrolled at 25 institutions where the Institutional Review Board approved the accompanying study. The 1st analysis on the predictive value of %p2PSA and Phi for pathological reclassification is scheduled to be carried out after collection of sera from 200 patients (projected time: the end of 2015).
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| Free Research Field |
泌尿器科学
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