Individualized treatment for hypopharyngeal cancer according to metabolic tumor volume and induction chemotherapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390387
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Osaka University
• Principal Investigator: INOHARA Hidenori 大阪大学, 医学(系)研究科(研究院), 教授 (00273657)
• Co-Investigator(Kenkyū-buntansha): TODO Tsuyoshi 大阪大学, 大学院医学系研究科, 教授 (90163948)
• Research Collaborator: HANAMOTO Atsushi ; FUKUSUMI Takahito
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下咽頭癌 / 喉頭癌 / 喉頭温存 / 化学放射線療法 / metabolic tumor volume / GLUT1

Outline of Final Research Achievements

We have established that metabolic tumor volume of primary tumor is an independent prognostic factor of laryngectomy-free survival and overall survival in patients with locally advanced laryngeal or hypopharyngeal cancer who are treated with chemoradiotherapy in the setting of larynx preservation. On the other hand, we subcutaneously transplanted surgically excised specimens of hypopharyngeal cancer (F0) into immunodeficient mice, and allowed them to grow to mass (F1). We comprehensively analyzed proteins overexpressed in F1 compared with F0, and identified glucose transporter 1 (GLUT1). A series of in vitro experiments revealed that GLUT1 conferred radioresistance on cells. These results indicate that therapy targeting glucose metabolism will serve to improve clinical outcome of locally advanced laryngeal or hypopharyngeal cancer with radioresistance.

Free Research Field

医歯薬学