2014 Fiscal Year Final Research Report
Functional roles and potential clinical application of bone marrow-derived stem cells in tissue repair
| Project/Area Number |
24390398
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 骨髄由来幹細胞 / 脂肪幹細胞 / 血管内皮前駆細胞 / ファイブロサイト / 創傷治癒 |
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| Outline of Final Research Achievements |
Inguinal fat pads of GFP mice and wild-type mice were cross-transplanted beneath the scalp. At 1, 2, 4, and 12 weeks post-transplantation, grafted fat was evaluated. Bone marrow of GFP mice was transplanted to wild-type mice(after irradiation) and were analyzed as well. The majority of host-derived cells detected during remodeling of grafted fat were macrophages. At 12 weeks, mature adipocytes largely were derived from adipose stem/stromal cells (ASCs) of grafts. Although vascular wall graft, vascular endothelial cells originated equally from graft and host bone marrow. ASCs of regenerated fat were an admixture of grafted, host non-bone marrow, and host bone marrow cells. Above findings underscore the importance of ASCs in the grafted fat for adipocyte regeneration. Host bone marrow and local tissues contributed substantially to capillary networks and provided new ASCs.
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| Free Research Field |
形成外科
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