Epidemiological study of serum titers against V-antigens of gram-negative bacteria

2015 Fiscal Year Final Research Report

• Project/Area Number: 24390403
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: Sawa Teiji 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
• Co-Investigator(Kenkyū-buntansha): Moriyama Kiyoshi 杏林大学, 医学部, 准教授 (10296717) ; Ueno Hiroshi 京都府立医科大学, 医学(系)研究科, 講師 (20381965) ; Kurahashi Kiyoyasu 横浜市立大学, 大学病院, 准教授 (50234539) ; Amaya Fumimasa 京都府立医科大学, 医学(系)研究科, 准教授 (60347466) ; Hashimoto Soshi 京都府立医科大学, 医学(系)研究科, 客員講師 (60515279) ; Matsuyama Hiroki 京都府立医科大学, 医学(系)研究科, 客員講師 (80515289)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: グラム陰性菌 / V抗原 / 血清抗体価 / 三型分泌システム / 感染 / 免疫 / PcrV

Outline of Final Research Achievements

We made the following five recombinant V-antigen proteins of pathogenic gram-negative bacteria (Pseudomonas aeruginosa PcrV, Yersinia LcrV, Vibrio VcrV, Aeromonas AcrV, and Photolahbdus LssV). Then, we developed measurement system for human anti-V-antigen titers, and performed an epidemiological study to examine serum titers against these V-antigens in 200 volunteers. As a result, we found that there are wide variations in V-antigen titers and these variations may have some effects on the infectivity of individuals.

Free Research Field

集中治療医学