The feasibility study of hydrogen inhalation on outcome following out-oh hospital cardiac arrest

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390405
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Keio University
• Principal Investigator: HORI Shingo 慶應義塾大学, 医学部, 教授 (80129650)
• Co-Investigator(Kenkyū-buntansha): SANO Motoaki 慶應義塾大学, 医学部, 准教授 (30265798) ; SUZUKI Masaru 慶應義塾大学, 医学部, 講師 (70265916)
• Co-Investigator(Renkei-kenkyūsha): OHTA Shigeo 日本医科大学, 大学院医学研究科, 教授 (00125832)
• Research Collaborator: HAYASHIDA Kei 慶應義塾大学, 医学部, 助教 (20445258)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 水素吸入療法 / 心停止蘇生後

Outline of Final Research Achievements

This study is a translational research aimed at clinical application of hydrogen inhalation therapy (HIT) in out-of-hospital cardiac arrest (CA) patient. First, we verified the usefulness of hydrogen inhalation using a rat CA model. Brain function scores and survival rates in the HIT group were improved compared to the control group. It showed the most improvement effect by the combined use of HIT and therapeutic hypothermia. In addition, we evaluated the safety and efficacy of HIT for patients successfully resuscitated after CA. There were no side effects and clinical disadvantages. Four patients of all 5 eligible patients discharged from hospital with alert consciousness. We are planning to verify the efficacy of HIT for post-CA patients by multicenter randomized trial.

Free Research Field

救急医療