Identification and function of Ni-binding carrier protein that induce Ni allergy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390407
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Tohoku University
• Principal Investigator: SUGAWARA Shunji 東北大学, 歯学研究科(研究院), 教授 (10241639)
• Co-Investigator(Kenkyū-buntansha): KUROISHI Toshinobu 東北大学, 大学院歯学研究科, 助教 (30400261) ; ENDO Yasuo 東北大学, 大学院歯学研究科, 教育研究支援者 (50005039)
• Co-Investigator(Renkei-kenkyūsha): MURAMOTO Koji 東北大学, 大学院生命科学研究科, 教授 (90157800)
• Research Collaborator: KINBARA Masayuki ; BANDO Kanan
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 金属アレルギー / ニッケル / キャリア分子

Outline of Final Research Achievements

Metal ions are allergens that cause allergic contact dermatitis, and nickel (Ni) has been shown to be the most frequent metal allergens. Metal ions become antigens by binding with self-carrier proteins, but their identity is still unclear.
In this study, we identified an Ni-binding carrier protein that cause Ni allergy form LPS-sensitized murine serum. This protein directly bound to Ni ion and reduced the threshold of Ni concentration that require to induce Ni allergy, whereas it did not alter the quality of allergic reaction. Investigations are still under way to elucidate the mechanism by which this novel protein amplify Ni allergy.

Free Research Field

口腔免疫学