Exploration of bacterial factors that inactivate complement regulatory factors and induce invasive infectious diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390410
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Osaka University
• Principal Investigator: KAWABATA Shigetada 大阪大学, 歯学研究科(研究院), 教授 (50273694)
• Co-Investigator(Kenkyū-buntansha): TERAO Yutaka 新潟大学, 医歯学総合研究科, 教授 (50397717) ; SUMITOMO Tomoko 大阪大学, 大学院歯学研究科, 助教 (50423421) ; NAKATA Masanobu 大阪大学, 大学院歯学研究科, 准教授 (90444497)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: レンサ球菌 / 補体 / 免疫回避

Outline of Final Research Achievements

Evasion of the human immune system is a hallmark of pathogenic streptococci that cause invasive infections, and leads to exacerbation of pathological condition during the course of infection. In this study, we revealed that a group A streptococcal protease, SpeB, cleaves C1 esterase inhibitor, and the cleavage is attributable to bacterial survival and aberration of complement system. Moreover, we demonstrate a mechanism by which streptococcus species frequently isolated from subacute bacterial endocarditis evades neutrophil killing.

Free Research Field

細菌学