Clinical application of a novel disinfection system based on local administration of low concentration hydroxyl radicals

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390430
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Tohoku University
• Principal Investigator: SASAKI Keiichi 東北大学, 歯学研究科(研究院), 教授 (30178644)
• Co-Investigator(Kenkyū-buntansha): KANNO Taro 東北大学, 大学院歯学研究科, 助教 (30302160) ; HAYASHI Eisei 東北大学, 大学院歯学研究科, 大学院非常勤講師 (60375102) ; IKAI Hiroyo 東北大学, 大学院歯学研究科, 助教 (20431588) ; NAKAMURA Keisuke 東北大学, 大学院歯学研究科, 助教 (30431589) ; NIWANO Yoshimi 東北大学, 大学院歯学研究科, 教授 (40375184) ; KOHNO Masahiro 東京工業大学, 大学院生命理工学研究科, 教授 (70333226)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ヒドロキシルラジカル / 活性酸素 / フリーラジカル

Outline of Final Research Achievements

Bactericidal effect and biological safety of a novel therapeutic device utilizing a disinfection technique based on photolysis of hydrogen peroxide for the treatment of periodontal disease were evaluated in the present study. In addition, clinical study was conducted to compare the efficacy of the device in the treatment of periodontitis with that of conventional root debridement. In vitro bactericidal tests demonstrated that device exerted high bactericidal effect, whereas in vivo test showed that it did not cause adverse effect on the oral mucosa of rats. In the clinical study, it was demonstrated that the treatment using the device significantly reduced the probing pocket depth 3 months after the treatment than conventional root debridement. Thus, it is suggested that the periodontal treatment using the device may improve the effect of non-surgical periodontal therapy.

Free Research Field

歯科補綴