Development of implant/interconnected porous hydroxyapatite complex with adsorbed bFGF and poly-phosphate

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390435
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthetic dentistry
• Research Institution: Ohu University (2013-2014); Hiroshima University (2012)
• Principal Investigator: AKAGAWA Yasumasa 奥羽大学, 歯学部, 教授 (00127599)
• Co-Investigator(Kenkyū-buntansha): KUBO Takayasu 広島大学, 病院, 講師 (60240876) ; KORETAKE Katsunori 広島大学, 大学院医歯薬保健学研究院, 助教 (50346508) ; DOI Kazuya 広島大学, 大学院医歯薬保健学研究院, 助教 (80444686) ; MORITA Koji 広島大学, 病院, 助教 (30555149)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 複合体 / ポリリン酸 / ｂＦＧＦ / 連通多孔性ハイドロキシアパタイト

Outline of Final Research Achievements

We designed novel complex biomaterial to simultaneously restore bone and place implant. This complex was incorporated implant into interconnected porous calcium　hydroxyapatite (IP-CHA) with adsorbed bFGF and polyphosphate. We then tested this complex and evaluated its effect on subsequent boneregeneration and implant stability.Ｔhe results indicate that placed complex could achieve osteoconduction of newly formed bone and osseointegration at the implant interface. We concluded that the Implant/IP-CHA complex could be expected to achieve bone reconstruction and implant stability.

Free Research Field

歯科補綴学