Antibacterial and osteogenic properties on hydrophilic-modified hydroxyapatite coating on titanium

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390445
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Showa University
• Principal Investigator: MIYAZAKI Takashi 昭和大学, 歯学部, 教授 (40175617)
• Co-Investigator(Kenkyū-buntansha): SHIBATA Yo 昭和大学, 歯学部, 講師 (30327936) ; MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343) ; YAMADA Atsushi 昭和大学, 歯学部, 講師 (50407558)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: チタン / インプラント / ハイドロキシアパタイト / コーティング / 抗菌

Outline of Final Research Achievements

Preparation of hydroxyapatite (HA) coated titanium (Ti) by electrical discharge in a buffered physiological saline solution has several advantages over traditional techniques. Specifically, it can generate highly crystalline nanoscale HA with a thickness of 1 μm. This study examined in vitro osteoblast gene expression and antimicrobial activity against early and late colonizers of supra-gingival plaque on nanoscale HA-coated Ti prepared by discharge in a physiological buffered solution. The sintered HA and HA-coated Ti surfaces enhanced osteoblast phenotypes in comparison with the bare Ti surface. The HA-coated Ti enabled antimicrobial activity against early colonizers of supra-gingival plaques, namely Streptococcus mitis and Streptococcus gordonii. Such antimicrobial activity may be caused by the surface hydrophilicity, thereby leading to a repulsion force between the HA-coated Ti surface and the bacterial cell membranes.

Free Research Field

歯科理工学