Development of novel implants with local administration of fluvastatin-gelatin complex

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390446
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Tokyo Dental College
• Principal Investigator: YOSHINARI Masao 東京歯科大学, 歯学部, 教授 (10085839)
• Co-Investigator(Renkei-kenkyūsha): MIURA Tadashi 東京歯科大学, 歯学部, 准教授 (10266570)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: フルバスタチン / 局所投与 / 薬剤徐放 / 低代謝型骨粗鬆症 / 骨形成促進 / インプラント / 母床骨改善

Outline of Final Research Achievements

Statins were recently reported to promote the differentiation of osteoblasts produced by the stimulation of BMP-2. This study aimed to clarify the efficacy of a local administration of fluvastatin, hydrophilic statin, on the healing of bone defects in low-turnover osteoporosis patients using a fluvastatin-gelatin complex.
Fluvastatin was released gradually from fluvastatin-gelatin complex with the dissolving gelatin that enabled the local administration of the fluvastatin. The fluvastatin-gelatin complex enhanced the bone formation in low-turnover osteoporosis animals, indicating that the fluvastatin-gelatin complex is promising carrier for facilitating the bone formation in low-turnover osteoporosis patients.

Free Research Field

歯科材料学・インプラント学