2016 Fiscal Year Final Research Report
EMT-dependent mechanism of local invasion of oral cancer cells
| Project/Area Number |
24390454
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
飛梅 圭 広島大学, 医歯薬保健学研究院(歯), 准教授 (40350037)
|
|---|
| Research Collaborator |
SHIGEISHI HIDEO 広島大学, 大学院医歯薬保健学研究院(歯), 助教 (90397943)
UETSUKI RYO 広島大学, 大学病院, 医員
|
|---|
| Project Period (FY) |
2012-04-01 – 2017-03-31
|
| Keywords | EMT / 口腔癌 / 癌の浸潤・転移 |
|---|
| Outline of Final Research Achievements |
Treatment prognosis for oral cancer depends on local invasion and metastasis. Epithelial mesenchymal transition (EMT) is regarded as an important event in acquiring cell motility in cancer cells, and it is deeply involved in treatment resistance such as apoptosis tolerance. This study investigated the role of EMT in local invasion of oral cancer and the formation of local invasive foci. Both transcription factors Snail and Slug were involved in the EMT induction, and newly found ZIP 2 as a regulatory factor. Moreover, local invasive foci found out that the preceding EMT cells regulate the cell motility of the subsequent non-EMT cancer cells with the external factor CCN1, and elucidated the mechanism of the local invasion of oral cancer.
|
| Free Research Field |
癌の分子生物学
|
