Development of tailor-made intra-arterial chemotherapy using patient specific computational fluid dynamics

2014 Fiscal Year Final Research Report

• Project/Area Number: 24390459
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Yokohama City University
• Principal Investigator: TOHNAI Iwai 横浜市立大学, 医学(系)研究科(研究院), 教授 (50172127)
• Co-Investigator(Kenkyū-buntansha): IWAI Toshinori 横浜市立大学, 附属病院, 助教 (00468191) ; MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641) ; OSHIMA Mari 東京大学, 大学院情報学環, 教授 (40242127)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 口腔癌 / 動注化学療法 / 流体解析 / シミュレーション

Outline of Final Research Achievements

Object of this study is to clarify anticancer drug distribution in retrograde intra-arterial chemotherapy for oral cancer using computational fluid dynamics. Carotid artery models were made using CT angiography, and catheter also was modeled. Blood flow simulation of carotid artery was performed using ultrasound data of carotid artery and peripheral vessels model. This study showed that blood flow into the lingual artery was limited even if catheter tip was located inferior branch of the lingual artery.

Free Research Field

口腔外科学