Construction of a program for sustainable use of traditional medicines, based on integrated study of genetic, chemical and pharmacological diversity of medicinal plants

2014 Fiscal Year Final Research Report

• Project/Area Number: 24406005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Environmental pharmacy
• Research Institution: University of Toyama
• Principal Investigator: KOMATSU Katsuko 富山大学, 和漢医薬学総合研究所, 教授 (50225570)
• Co-Investigator(Kenkyū-buntansha): TOHDA Chihiro 富山大学, 和漢医薬学総合研究所, 准教授 (10272931) ; KADOWAKI Makoto 富山大学, 和漢医薬学総合研究所, 教授 (20305709) ; ZHU Shu 富山大学, 和漢医薬学総合研究所, 助教 (20377360)
• Co-Investigator(Renkei-kenkyūsha): KAZUMA Kohei 富山大学, 和漢医薬学総合研究所, その他 (70552446)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 薬用植物 / 品質評価 / 芍薬 / 刺五加 / Gentiana属生薬 / 痴呆 / アレルギー疾患 / 国際協力

Outline of Final Research Achievements

To develop an active plan for sustainable use of herbal drug resources, field investigation on botanical sources and genetic, chemical and pharmacological analyses were performed to establish indices for standardization of 7 herbal drugs. Subsequently plants with superior or characteristic properties were selected upon integrated survey and analyses on medicinal resources related to each drug including horticultural cultivars, and their cultivation was initiated. Two cultivars were selected as candidate source for red peony root based on genetic, chemical and pharmacological characteristics. A superior strain of rhubarb with multi-components was selected. The hot water extract of leaves of hydroponic cultured siberian ginseng showed neurite outgrowth activity. In the study on 2 kinds of Gentiana drugs, genetic and chemical markers for identification besides compounds with anti-inflammatory activity were determined, which gave the information to select alternative source of these drugs.

Free Research Field

生薬学、薬用植物学、天然物化学