2014 Fiscal Year Final Research Report
Studies on modifying factors for arsenic toxicity in arsenic-endemic areas in Asia
| Project/Area Number |
24406009
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUMI Daigo 徳島文理大学, 薬学部, 准教授 (30400683)
MIYATAKA Hideki 徳島文理大学, 薬学部, 助教 (50157658)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ヒ素 / アジア / 地下水汚染 / 免疫能力 / ヒ素解毒能力 |
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| Outline of Final Research Achievements |
Health hazards caused by arsenic pollution of tube-well water are endemic in Asian countries. We have collected the samples of hair, nail, blood, urine, and drinking water from Bangladesh and Cambodian residents to assess the dose-response relationship between the levels of arsenic exposure and health effects. In Bangladesh, we found that elevating levels of arsenic exposure were well correlated with biochemical indicators for hepatotoxicity, atherosclerosis, and hypertension. In Cambodia, the contribution of tube-well water as well as the consumption of fish and rice to arsenic exposure was investigated. Chemical forms of arsenic in freshwater fish in Cambodia were precisely evaluated. In a cell culture system, we found that alternative splicing of the gene for arsenic methylation (detoxifying) enzyme could be a cause for individual difference in sensitivity to arsenic toxicity. Also, we found that arsenic exposure reduces the ability of natural killer cells for killing tumor cells.
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| Free Research Field |
環境毒性学
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