Investigation of the transmission dynamics of MDR- and XDR-tuberculosis in Asian countries

2015 Fiscal Year Final Research Report

• Project/Area Number: 24406021
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Public health/Health science
• Research Institution: Hokkaido University
• Principal Investigator: Suzuki Yasuhiko 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
• Co-Investigator(Kenkyū-buntansha): NAKAJIMA CHIE 北海道大学, 人獣共通感染症リサーチセンター, 特任助教 (60435964)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 多剤耐性結核 / 超多剤耐性結核 / 遺伝子型別

Outline of Final Research Achievements

We selected Nepal, Bangladesh, Myanmar, Thailand and the philippines as the countries without sufficient investigation of multidrug-resistant (MDR)- and extensively drug resistant (XDR)-tuberculosis (TB). We isolated 2208 Mycobacterium tuberculosis strains from those who were showing tuberculosis or tuberculosis-like symptoms and stored as strain banks in each country. In addition, we extracted DNA from these strains and stored as DNA bank in both Japan and those countries.
By genotyping and the analysis of drug resistance associating gene mutations, we found that many of the MDR- and XDR-TB were caused by M. tuberculosis strains with Beijing genotype and the strains were showing rapid transmission dynamics.

Free Research Field

細菌学