Bioinformatic study on functional RNAs with a conformational change

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: Hirosaki University
• Principal Investigator: TANEDA Akito 弘前大学, 理工学研究科, 准教授 (70332492)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 進化的計算 / 多目的最適化 / RNA工学 / 人工リボスイッチ

Outline of Final Research Achievements

We have developed a novel algorithm for designing functional RNAs with conformational changes such as artificial riboswitches. By using the method developed in the present study, by virtue of a multi-objective genetic algorithm which was employed in the present study, we can design RNA sequences which not only have multistable structures but also have various specified features such as an energy barrier height and the GC content without empirical weight parameters among the objective functions. We compared the present method with the previous design methods (RNAdesign and Frnakenstein) and found that the present method shows comparable or better design performances compared to the previous methods.

Free Research Field

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