Elucidation of the Brain Operating Principles by Analyzing Large Scale Neuron-Astrocyte Networks with Genetic Algorithm

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Bioinformatics/Life informatics
• Research Institution: The Institute of Statistical Mathematics
• Principal Investigator: TAMURA Yoshiyasu 統計数理研究所, モデリング研究系, 教授 (60150033)
• Co-Investigator(Kenkyū-buntansha): SOMEYA Hiroshi 東海大学, 情報理工学部, 講師 (00333518) ; OKU Yoshitaka 兵庫医科大学, 医学部, 教授 (20252512) ; OKADA Yasumasa 独立行政法人国立病院機構村山医療センター(臨床研究センター), 電気生理学研究室, 室長 (80160688)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カルシウムイメージング / アストロサイト

Outline of Final Research Achievements

By calcium imaging, we recorded activities of neurons and astrocytes in the brainstem respiratory center of the rat and mouse, and found a subset of astrocytes of which activities preceded inspiratory neural output. By time series analysis of the imaging data and neural respiratory output and by computer simulation of the rhythm generating neuron-astrocyte networks, we concluded that respiratory rhythm is generated by loosely coupled intrinsically oscillating neurons and astrocytes.

Free Research Field

計算統計学