Orexinaergic modulation of respiration in the brainstem; a comparison between adult and infant animal.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500380
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Shimane University
• Principal Investigator: YOKOTA Shigefumi 島根大学, 医学部, 助教 (50294369)
• Co-Investigator(Renkei-kenkyūsha): YASUI Yukihiko 島根大学, 医学部, 教授 (30174501) ; OKADA Yasumasa 独立行政法人国立病院機構村山医療センター(臨床研究センター), 電気生理学研究室, 室長 (80160688) ; TSUMORI Toshiko 県立広島大学, 保健福祉学部, 教授 (30217377) ; OKA Tasuro 島根大学, 医学部, 助教 (20508923)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: オレキシン / 結合腕傍核 / 腹側呼吸ニューロン群吻側部 / 横隔神経核 / 舌下神経核 / オレキシンレセプター2

Outline of Final Research Achievements

To understand the neural pathways underlying the respiratory variation dependent on sleep/wake states, we examined the orexinergic projection to the parabrachial nucleus. The results of the present study are as follows: (1) in adult, orexin may exert modulatory influence through orexin receptor 2 upon Kolliker-Fuse neurons which send their axons to the rostral ventral respiratory group and phrenic nucleus for eliciting the repiratory facilitation and to the hypoglossal nucleus for eliciting the maintaining the airway patency during wakeful state; (2) in infant, overlapping distribution of orexin-immunoreactive fibers and rostral ventral respiratory group projecting neurons is found in the Kolliker-Fuse nucleus, and orexin B injection into the lateral parabrachial nucleus of the brainstem-spinal cord preparation results in facilitation of respiration.

Free Research Field

神経解剖学