2014 Fiscal Year Final Research Report
Characterization of newborn interneurons in the mouse olfactory bulb
| Project/Area Number |
24500385
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIHARA Sei-ichi (90360669)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 嗅球 / 新生ニューロン |
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| Outline of Final Research Achievements |
Olfactory bulb (OB) interneurons, such as periglomerular cells and granule cells, are generated in the subventricular zone of lateral ventricle and integrated into the pre-existing neural circuit throughout the life. However, it remains unknown how the interneurons migrate and are integrated into the pre-existing neural circuit within the OB.
To study the migration process of interneurons in the OB, we performed the time-lapse imaging of slice cultures. Although it was previously reported that blood vessels act as a scaffold for the interneurons, we found that some interneurons moved along blood vessels, but others utilized another interneuron as a scaffold to migrate radially within the OB. These results suggest that cell-cell interactions between interneurons play an important role of the neuronal migration in the OB.
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| Free Research Field |
神経科学
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