Activity-Dependent Notch signaling is required for the barrel formation in the somatosensory system of mouse brains.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24500387
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: Saitama Medical University
• Principal Investigator: Nakao Keiko 埼玉医科大学, 医学部, 講師 (70338185)
• Co-Investigator(Kenkyū-buntansha): ITAMI Chiaki 埼玉医科大学, 医学部, 講師 (90392430) [Withdrawn]
• Co-Investigator(Renkei-kenkyūsha): HOSHINO Mikio 独立行政法人国立精神・神経医療研究センター, 神経センター病態生化学研究部, 部長 (70301273)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: Notch シグナル / 神経活動依存的シグナル伝達 / 子宮内電気穿孔法 / c-Fos / barrel cortex

Outline of Final Research Achievements

Notch signaling has a key role in cell fate specification in the developping brains. However Notch related genes are continuously expressed in the postmitotic neurons after completion of the last cell division. Notch signaling is activated in the c-Fos positive neurons. Downregulation or overexpression of Notch caused disruption of barrel cortex, suggestion that Notch signaling is required for the barrel formation in the developing mouse brains.

Free Research Field

神経発生過程におけるNotchシグナリングの機能