Identification of the endocytosis regulator that determines the polarity of neuronal axon guidance

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500393
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOJIMA Takuro 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (00373332)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 成長円錐 / 軸索ガイダンス / クラスリン依存性エンドサイトーシス / PIPKIgamma90 / AP2

Outline of Final Research Achievements

During embryonic development, axonal growth cones are guided along their correct routes toward distant targets by a variety of extracellular attractive and repulsive cues. We previously demonstrated that growth cone repulsion, but not attraction, is driven by asymmetric clathrin-mediated endocytosis across the growth cone. In the present study, we identify a 90 kDa splice variant of phosphatidylinositol-4-phosphate 5-kinase type-1 gamma (PIPKIgamma90) as an endocytosis-adaptor protein that mediates growth cone repulsion.

Free Research Field

神経科学