The role of Rab effector protein in the AMPA receptor trafficking associated with neural activity history

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500400
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neuroscience in general
• Research Institution: National Institute of Advanced Industrial Science and Technology
• Principal Investigator: KIYOSUE Kazuyuki 独立行政法人産業技術総合研究所, バイオメディカル研究部門, グループリーダー (50356903)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 膜輸送 / シナプス可塑性 / 受容体

Outline of Final Research Achievements

The function of synapses is defined largely by the receptor subunits to be transported, the control mechanism by a membrane transport including endosome and recycling endosome, is largely unknown. We focus on rabaptin-5, an effector protein of Rab5, in glutamate receptor trafficking, and have found as following points. 1) Rabaptin-5 is involved in subunit-specific transport of glutamate receptor, 2) activity-dependent changes in the Rabaptin-5 depending on the neural activity history, 3) contribution to the homeostatic synaptic plasticity. These results indicates that membrane transport route through the recycling from endosomes is critical for synaptic function and plasticity expression.

Free Research Field

神経科学