Functional significance of angiogenesis in the circumventricular organs

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500411
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kyoto Institute of Technology
• Principal Investigator: MIYATA Seiji 京都工芸繊維大学, 工芸科学研究科, 准教授 (30243124)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 血管新生 / 神経幹細胞 / 血液脳関門 / 血管透過性 / 血管基定膜 / タイトジャンクション / TRPV1 / TLR4

Outline of Final Research Achievements

The circumventricular organs (CVOs) do not express tight junction proteins and hence lack blood-brain barrier (BBB) and possess high vascular permeability. The present study demonstrates the presence of continuous angiogenesis and neurogenesis in the CVOs of adult mice. Continuous angiogenesis and neurogenesis contributes to tissue reconstruction and plasticity. Moreover, the basement membrane and GFAP-positive neural stem cells function as barrier instead of usual BBB. GFAP-positive neural stem cells detect blood-derived information via sensory protein TRPV1 and TLR4 and thereafter send information to adjacent neurons. Thus, the CVOs the dynamic brain regions accompanied with angiogenesis and neurogenesis.

Free Research Field

神経科学