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2014 Fiscal Year Final Research Report

Dynamics of PML-NBs and potential oncogenecity in JC virus-infected cells

Research Project

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Project/Area Number 24500421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKyorin University

Principal Investigator

SHISHIDO-HARA Yukiko  杏林大学, 医学部, 講師 (40313267)

Co-Investigator(Kenkyū-buntansha) KAMMA Hiroshi  杏林大学, 教授 (10195191)
YAZAWA Takuya  千葉大学, 医学(系)研究科, 准教授 (50251054)
Project Period (FY) 2012-04-01 – 2015-03-31
Keywords進行性多巣性白質脳症 / JCウイルス / 細胞周期 / PML-NBs / DNA複製 / 細胞変性 / 細胞腫瘍化
Outline of Final Research Achievements

Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder caused by JC virus infection. Histopathologically, infected oligodendroglia-like cells display two distinctive inclusion patterns: full inclusions in which progeny virions occupy throughout the enlarged nucleus and dot-shaped inclusions in which virions are clustered at subnuclear domains called promyelocytic leukemia nuclear bodies (PML-NBs). In this study, we clarified that nuclei of infected oligodendrocytes enlarge with cell cycle transition from S to G2-like state. PML-NBs also enlarge during this process, and the virus re-produce progenies. Eventually, PML-NBs are dispersed by propagating viruses. Therefore PML-NBs serve a scaffolding role for viral progeny production however it remains unclear why the virus-infected oligodendrocytes undergo cell death but not mitosis, after cell cycle transition from S to G2.

Free Research Field

神経病理学

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Published: 2016-06-03  

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