Synuclein pathology of Multipul system atrophy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500425
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Aichi Medical University
• Principal Investigator: MIMURO Maya 愛知医科大学, 付置研究所, 助教 (20387814)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 多系統萎縮症 / レビー小体病 / αシヌクレイン

Outline of Final Research Achievements

Both Multiple system atrophy (MSA) and Lewy body disease are major degenerative disorders. Pathologically, both diseases show abnormal α-synuclein aggregation, and also called Synucleinopathy. To clarify the relationship between MSA and Lewy-related pathology, we examined 160 autopsy confirmed cases of MSA at our institute. First, we examined frequency of Lewy-related pathology in MSA. Eleven of 160 cases (6.9%) at central nervous system and 10 of 35 cases at peripheral nervous system showed Lewy pathology. Next, we examined frequency of the swollen neurites in MSA. Twenty three of 160 cases (14.4%) showed these swollen neurites. At last, we examined frequency of synuclein-positive structures at sympathetic ganglia in MSA. Interestingly, forty of 65 cases (62.1%) showed synuclein-positive structures there. Taken together, we suggest MSA would show abnormal α-synuclein aggregation at neurite and peripheral nervous system without Lewy-related pathology

Free Research Field

神経病理学