2014 Fiscal Year Final Research Report
The analysis of brain damage by dysfunction of the endoplasmic reticulum signaling
| Project/Area Number |
24500440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Yasuda Women's University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞生物学 / 神経科学 |
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| Outline of Final Research Achievements |
To elucidate the role of endoplasmic reticulum stress signaling in brain development, we examined the brain of PERK-deficient mice. We showed that the size of whole brain and olfactory bulb were smaller in PERK-deficient mice. In addition, the endoplasmic reticulum stress occurs in mouse subplate neurons at developmental stage. These results suggest that ER stress response have the important role in brain development.
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| Free Research Field |
細胞生物学
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