2014 Fiscal Year Final Research Report
Neuroprotection via lipoprotein receptors against optic neuropathy
| Project/Area Number |
24500441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo University of Pharmacy and Life Science (2013-2014)
Kumamoto University (2012) |
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Principal Investigator |
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| Research Collaborator |
VANCE Jean E. アルバータ大学, 医学部, 教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | リポ蛋白 / 緑内障 / グルタミン酸 |
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| Outline of Final Research Achievements |
The leading cause of blindness in Japan is glaucoma, which is one of neurodegenerative disorders. We have previously demonstrated that apolipoprotein E-containing lipoproteins strongly protect primary cultured retinal ganglion cells from trophic factors-withdrawal-induced neurodegeneration. In this study, we showed a neuroprotective mechanism of apolipoprotein E-containing lipoproteins via the lipoprotein receptor against glutamate-induced neurotoxicity. We believe that the results of this study provide a novel therapeutic approach for glaucoma.
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| Free Research Field |
神経科学
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