The association between non-motor symptom and visual hallucination in Parkinson disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500458
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Nagoya University
• Principal Investigator: HIRAYAMA Masaaki 名古屋大学, 医学(系)研究科(研究院), 准教授 (30283435)
• Co-Investigator(Kenkyū-buntansha): WATANABE Hirohisa 名古屋大学, 医学部神経内科, 講師 (10378177) ; NAKAMURA Tomohiko 名古屋大学, 医学部附属病院, 助教 (00437039) ; SOBUE Gen 名古屋大学, 医学部神経内科, 教授 (20148315)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 幻覚 / パーキンソン病 / 脳磁図 / 網膜 / 非運動症状

Outline of Final Research Achievements

We tried to detect the changes of aging and Parkinson’s disease (PD) in the visual evoked brain response to the primary visual cortex.We measured visual evoked magnetic field (VEF) using MEG. Checker pattern reversal (CPR) and monotonous grating pattern (MGP) stimulation were used.Cognitive function test, the smell test and UPDRS were evaluated in the PD. In CPR stimulus, the latency of 2M and 3M in the elderly had significantly delayed than the younger. The current of 1M, 2M and 3M were significantly greater and the latency of 1M was delayed markedly in the PD, which compared to the elderly. In the PD, 1M latency correlated with UPDRS-1, 3 in both stimuli, and it also correlated with the smell test in CPR stimulus. Diffusion tensor imaging was significantly different between younger and elderly, but no difference was found between PD and elderly. It was suggested that conduction delay corresponding to the checker stimulus occurred in peripheral than the primary visual cortex.

Free Research Field

神経内科