2015 Fiscal Year Final Research Report
Modulation of striatal synaptic tramsmission by cell surface and intracellular functionbal molecules
| Project/Area Number |
24500464
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | ドーパミン / ムスカリン / セロトニン / 線条体 / 海馬 / 前脳基底核 / パッチクランプ / シナプス伝達 |
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| Outline of Final Research Achievements |
Central synaptic transmission is regulated by various molecules on the surface of cell membranes as well as in the cytosoles. In the present grant project, I have clarified 1) modulatory roles of intracellular muscarinic receptor M1 subtype in the regulation of long term potentiation in the hippocampal excitatory synaptic transmission, 2) functions of physiologically released dopamine in the inhibitory synapse and neuronal activities in the striatum, 3) presynaptic inhibition of inhibitory synaptic transmission in the basal forebrain by serotonin 5-HT1B receptors. I'm also analyzing the functions of intracellular transcription factors in the excitatory anｄ inhibitory transmission in the striatum.
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| Free Research Field |
神経生理学
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