2014 Fiscal Year Final Research Report
Investigation of microglial activation through noradrenaline in the process of neurodegenerative disease
Project/Area Number |
24500465
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurophysiology and muscle physiology
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Research Institution | Nippon Medical School |
Principal Investigator |
SUGAMA Shuei 日本医科大学, 医学部, 講師 (70302461)
|
Co-Investigator(Renkei-kenkyūsha) |
HASHIMOTO Makoto (50189502)
TAKENOUCHI Takato (20292518)
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Project Period (FY) |
2012-04-01 – 2015-03-31
|
Keywords | ミクログリア / ストレス / ノルアドレナリン / 青斑核 / アドレナリン受容体 / 脳内免疫 |
Outline of Final Research Achievements |
We have demonstrated the first evidence that acute stress could induce morphological microglial activation in the brain. The goal of this study was to investigate the mechanism how the microglial activation is triggeredd by exposures to acute stress. We found that Dopamine beta Hydroxylase (DBH), an enzyme required for the synthesis of noradrenaline in the brain, is significantly elevated in the hippocampus, thalamus, and hypothalamus in response to acute stress. In addition, we found that DBH immunoreactive fibers surround microglial cells. Those microglial cells were found to be positive to beta 1 and beta 2 Adrenergic Receptor (AR). We suggest that microglia may be modulated through noradrenaline during the time of acute stress.
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Free Research Field |
神経科学
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