Analysis of MG56: sarcoplasmic reticulum-resident protein

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurophysiology and muscle physiology
• Research Institution: Kyoto University
• Principal Investigator: NISHI Miyuki 京都大学, 健康長寿社会の総合医療開発ユニット, 准教授 (60183894)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 骨格筋 / カルシウム / 小胞体

Outline of Final Research Achievements

Mitsugumin 56 (MG56), also known as the membrane-bound O-acyl-transferase family member hedgehog acyltransferase-like, was identified as a new sarcoplasmic reticulum component in striated muscle. Mg56-knockout mice grew normally for a week after birth, but shortly thereafter exhibited a suckling defect and died under starvation conditions. In the knockout skeletal muscle, regular contractile features were largely preserved, but sarcoplasmic reticulum elements swelled and further developed enormous vacuoles. In parallel, the unfolded protein response was severely activated in the knockout muscle, and presumably disrupted muscle development leading to the suckling failure. Therefore, MG56 seems essential for postnatal skeletal muscle maturation.

Free Research Field

生化学