Astricyte dynamics in synaptic plascitity in vivo

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Fusional basic brain science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TSUNEKO Mishima 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 (90415307)
• Co-Investigator(Renkei-kenkyūsha): HIRASE Hajime 理化学研究所, 脳科学総合研究センター, 神経グリア回路研究チームリーダー (90392084)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: アストロサイト / 可塑性 / 二光子イメージング / ウイルス / 慢性計測 / バレル

Outline of Final Research Achievements

We investigated the role of glial cells in　synaptic plasticity by analyzing a change in the microenvironment　surrounding neurons occurs plasticity in vivo, in particular the　dynamics of glial cells (astrocytes).　①Protocol for induce cortical plasticity under physiological conditions, and to visualize astrocytes surrounding synapses were examined and established.　②Animal fix device development for chronic imaging of astrocytic processes structure using two-photon microscope was achieved.　③Analyzing those imaging data (including making program in Matlab). Consequently astrocytes found to have varied over time form by plasticity induction, the time course is currently being analyzed.

Free Research Field

神経生理学