Sox17 haploinsufficiency as applied to human disease model for newborn hepatitis.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500485
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KANAI MASAMI 東京医科歯科大学, 実験動物センター, 教授 (70321883)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: へテロ不全 / 疾患モデル動物 / 新生児肝炎 / Sox17

Outline of Final Research Achievements

In this study, we have observed the phenotype about the condition of a patient of the newborn hepatitis that showing Sox17 haploinsufficiency comparative with Sox17 conditional knockout lines for liver, pancreas and gallbladder, morphologically. In addition, as a candidate of the new human disease model, we confirmed gene introduction efficiency by use of TARGATT (the transgenic mouse system which can control a copy number in site specific). We will apply it as a disease model compared with Sox17 heterozygous mouse and point mutated SHIVA mouse (Met 72 mutated to Arg; with the liver metabolism abnormality symptom).

Free Research Field

実験動物