2015 Fiscal Year Final Research Report
Identification of virulence associations and host response in Pasteurella pneumotropica.
Project/Area Number |
24500497
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
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Research Institution | Juntendo University (2013-2015) Tokyo Medical University (2012) |
Principal Investigator |
Sasaki Hiraku 順天堂大学, スポーツ健康科学部, 准教授 (20384969)
|
Co-Investigator(Renkei-kenkyūsha) |
KAWAMOTO Eiichi 東京医科大学, 医学部, 准教授 (20074718)
ISHIKAWA Hiroki 東京医科大学, 医学部, 助教 (60433918)
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Project Period (FY) |
2012-04-01 – 2016-03-31
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Keywords | 肺パスツレラ / リン酸化 / ドラフトゲノム |
Outline of Final Research Achievements |
Pasteurella pneumotropica is an opportunistic pathogen for rodents and is one of preventive pathogens for managing health of laboratory animals. The objectives of this study were to identify virulence associations and to clarify relationships between P. pneumotropica pathogenesis and host cell response. In this study, additional RTX toxin, IbpA and YadA were identified in P. pneumotropica. Of these, IbpA is involved in tyrosine-phosphorylation in murine macrophage cells by the Src family kinase. YadA is indispensable for adherent against host fibroblast cells and extracellular matrix. These virulence associations are required for P. pneumotropica pathogenesis.
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Free Research Field |
微生物学、実験動物学、 細菌学、 応用微生物学
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