Diffuse Correlation Imaging for Diagnosis of Biological Tissue

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500504
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Hokkaido University
• Principal Investigator: NISHIMURA Goro 北海道大学, 電子科学研究所, 助教 (30218193)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: diffuse correlation / photon correlation / photon counting / fluorescence correlation / tissue diagnosis

Outline of Final Research Achievements

The project aimed to establish a diagnosis technology by means of diffuse correlation imaging. In the project, a multi-point high time-resolution photon counting system was constructed for a multiple correlation analysis of the scattering photon through biological tissue. In addtion, a time-resolved system for the scattering photon was combined to determin optical parameters such as the absorption and scattering coefficients. The system was successifully applied for measurements of phantom and rat abnodominal tissue, yielding the scattering, absorption coefficients and correlation time, which carries the information of tissue structure, blood absorption and blood flow, respectively. Finally, the 2D image could be obtained to visualize these parameters. This novel technology will extend current optical methods for diagnosis of biological tissue.

Free Research Field

医用生体光学