2014 Fiscal Year Final Research Report
Novel Therapeutic Approach for Orthostatic Hypotension: Deep Brain Stimulation
| Project/Area Number |
24500511
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMASAKI Fumiyasu 高知大学, 教育研究部医療学系, 講師 (10243841)
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| Co-Investigator(Renkei-kenkyūsha) |
SATO Takayuki 高知大学, 教育研究部医療学系, 教授 (90205930)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 先端機能デバイス / 医療・福祉 / 医療工学 / 起立性低血圧 / 低侵襲治療システム |
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| Outline of Final Research Achievements |
To develop an artificial feedback system for treatment of orthostatic hypotension due to autonomic failure, we examined dynamic responses of arterial pressure (AP) to deep brain stimulation (DBS). 1) We confirmed whether AP reacts to DBS preliminary in 25 Parkinson‘s disease(PD) patients treated with DBS to STN (subthalamic nucleus). In 37 trials, 10 (27%) were increased over 3mmHg, 21 (57%) were not changed, and 6 could not be measured by stimulating discomfort. 2) We randomly stimulated the STN every 8 sec, while measuring AP tonometrically. In 12 PD patients treated with DBS, 21 trials were tested. We calculated the frequency response of AP to the DBS with an FFT algorithm. Finally, we computed a step response of AP to DBP. The frequency responses were identifiable in 11 trials. The step response function showed AP quickly responded to the DBP and reached 90% of the steady-state response in 10 sec. The steady state gain was 0.015±0.013 mmHg/Hz.
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| Free Research Field |
循環器内科
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