2014 Fiscal Year Final Research Report
Composite imaging method for histological image analysis
| Project/Area Number |
24500514
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Shibaura Institute of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Masayuki 横浜市立大学, 医学部, 教授 (00092073)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 画像解析 / 診断支援 / 病理診断 / 病理組織 / 暗視野 / 位相差 / 光学顕微鏡 / 肝臓 |
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| Outline of Final Research Achievements |
A composite imaging method has been developed that enables the user to directly capture a composite image by one-image capturing. The composite images of bright-field, dark-field, and phase-contrast images can be captured with an arbitrary composition ratio. Both different channels of different capturing methods and two dark-field images with different illumination directions can also be captured by one-image capturing. Three kinds of images and their composite images were useful to improve both the visibility and the accuracy for extracting Helicobacter pylori in HE-stained gastric histological sections. Those images were also useful for improving the visibility and the accuracy for image analysis of both HE-stained and unstained liver sections. A method for estimating and visualizing the distributions of features in hepatic histological sections was also developed. A part of developed functions were introduced in a diagnosis support system to extract useful features.
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| Free Research Field |
画像処理，画像計測，画像認識，画像応用システム，医用画像
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