Effect of hyperthermia on mechanical property of cancer cell

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500523
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Okayama University of Science
• Principal Investigator: NAIKI Takeru 岡山理科大学, 工学部, 教授 (40241385)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Kozaburo 岡山理科大学, 工学部, 教授 (90026196) ; MATSUKI Noriaki 岡山理科大学, 工学部, 教授 (90284520) ; HARA Hirofumi 岡山理科大学, 工学部, 准教授 (80511071)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ハイパーサーミア / 細胞骨格 / 細胞生存率 / 細胞スティフネス / 原子間力顕微鏡 / がん治療

Outline of Final Research Achievements

Hyperthermia is the technique that induces cell death only in cancer cells by heat stimulation. In the present study, the effects of heat stimulation on the structure of cytoskeletons and cell stiffness were analyzed. As the results of the study, the structures of actin fibers, microtubules, and desmosomes changed by heat stimulation, and the differences between living cells and dying cells were observed at about 40 minutes after stimulation. The techniques to measure cell stiffness by atomic force microscope and make the cancer models in mice were developed.Hyperthermia is the technique

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