2014 Fiscal Year Final Research Report
Development of Matrigel mimicked biomaterial
| Project/Area Number |
24500530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞外マトリックス / 基底膜 / マトリゲル / ラミニン / ペプチド / 高分子多糖 / インテグリン / クロストーク |
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| Outline of Final Research Achievements |
Matrigel is one of the extensive and common cell culture matrices, which promotes cell adhesion and maintains the pluripotency of stem cells. The major component of Matrigel is laminin, a multi-functional extracellular matrix protein. Multi-laminin derived active peptides conjugated polysaccharide matrices are explored to develop the cell adhesive matrix that is mimicking the function of Matrigel. The biological activities of multi-peptide-polysaccharide matrices could control by the optimized selection and mixture ratios of different active peptides. These findings are critical to design the Matrigel mimicked biomaterials.
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| Free Research Field |
細胞生物学
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