2014 Fiscal Year Final Research Report
Development of immunoceramics acting on immune system and their functions
| Project/Area Number |
24500531
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Biomedical engineering/Biological material science
|
|---|
| Research Institution | Meiji University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Shigenori 東京医科歯科大学大学院, 医歯学総合研究科, 准教授 (50348801)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | イムノセラミックス / 水酸アパタイト / イノシトールリン酸 / ホウ素含有アパタイト / 免疫細胞 / T細胞 / フローサイトメーター / 養子免疫療法 |
|---|
| Outline of Final Research Achievements |
Calcium phosphates, such as hydroxyapatite (HAp) are one of the important key materials in the field of biomaterials. Immunotherapy without side effects has been expected as a novel medical treatment for a cancer. Among some immunotherapies, we have focused on the lymphokine activated killer cell (LAK) therapy. In order to develop the novel cell-culture substrates for enhancing the activity of immune cells, we have created the two kinds of “immunoceramics”: i) boron-containing apatite (BAp) with BO2 groups and ii) HAp ceramics surface-modified with inositol phosphate (IP6) (IP6-HAp ceramics). Splenocytes derived from the spleen of mouse were seeded on the above immnoceramics to assay the activation ability by a flow cytometry. The results showed that the populations of splenocytes with the immunoceramics were higher than that of the splenocytes with the HAp ceramics as a control. The two immunoceramics may be expected as key materials for next-generation immunotherapy.
|
| Free Research Field |
バイオマテリアル、バイオセラミックス
|
